Development of a High-Throughput Assay for Identifying Inhibitors of TBK1 and IKKε

IKKε and TBK1 are noncanonical IKK family members which regulate inflammatory signaling pathways and also play important roles in oncogenesis. However, few inhibitors of these kinases have been identified. While the substrate specificity of IKKε has recently been described, the substrate specificity...

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Detalles Bibliográficos
Autores principales: Hutti, Jessica E., Porter, Melissa A., Cheely, Adam W., Cantley, Lewis C., Wang, Xiaodong, Kireev, Dmitri, Baldwin, Albert S., Janzen, William P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408500/
https://www.ncbi.nlm.nih.gov/pubmed/22859992
http://dx.doi.org/10.1371/journal.pone.0041494

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408500/
https://www.ncbi.nlm.nih.gov/pubmed/22859992
http://dx.doi.org/10.1371/journal.pone.0041494

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