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Evidence for Inhibitory Effects of Flupirtine, a Centrally Acting Analgesic, on Delayed Rectifier K(+) Currents in Motor Neuron-Like Cells
Flupirtine (Flu), a triaminopyridine derivative, is a centrally acting, non-opiate analgesic agent. In this study, effects of Flu on K(+) currents were explored in two types of motor neuron-like cells. Cell exposure to Flu decreased the amplitude of delayed rectifier K(+) current (I (K(DR))) with a...
Autores principales: | Wu, Sheng-Nan, Hsu, Ming-Chun, Liao, Yu-Kai, Wu, Fang-Tzu, Jong, Yuh-Jyh, Lo, Yi-Ching |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408763/ https://www.ncbi.nlm.nih.gov/pubmed/22888361 http://dx.doi.org/10.1155/2012/148403 |
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