Ubiquitylation of active Rac1 by the E3 Ubiquitin-Ligase HACE1

Rho GTPases undergo ubiquitylation and degradation via the ubiquitin-proteasome pathway. We now report in the November issue of Developmental Cell that the E3 ubiquitin-ligase HACE1 catalyzes the ubiquitylation of GTP-bound Rac1. Depletion of HACE1 leads to an increase of Rac1 activity. We have prop...

Descripción completa

Detalles Bibliográficos
Autores principales: Mettouchi, Amel, Lemichez, Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408975/
https://www.ncbi.nlm.nih.gov/pubmed/22790197
http://dx.doi.org/10.4161/sgtp.19221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408975/
https://www.ncbi.nlm.nih.gov/pubmed/22790197
http://dx.doi.org/10.4161/sgtp.19221

Ejemplares similares