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Ubiquitylation of active Rac1 by the E3 Ubiquitin-Ligase HACE1
Rho GTPases undergo ubiquitylation and degradation via the ubiquitin-proteasome pathway. We now report in the November issue of Developmental Cell that the E3 ubiquitin-ligase HACE1 catalyzes the ubiquitylation of GTP-bound Rac1. Depletion of HACE1 leads to an increase of Rac1 activity. We have prop...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Landes Bioscience
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408975/ https://www.ncbi.nlm.nih.gov/pubmed/22790197 http://dx.doi.org/10.4161/sgtp.19221 |