Synthetic Spike-in Standards Improve Run-Specific Systematic Error Analysis for DNA and RNA Sequencing

While the importance of random sequencing errors decreases at higher DNA or RNA sequencing depths, systematic sequencing errors (SSEs) dominate at high sequencing depths and can be difficult to distinguish from biological variants. These SSEs can cause base quality scores to underestimate the probab...

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Detalles Bibliográficos
Autores principales: Zook, Justin M., Samarov, Daniel, McDaniel, Jennifer, Sen, Shurjo K., Salit, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409179/
https://www.ncbi.nlm.nih.gov/pubmed/22859977
http://dx.doi.org/10.1371/journal.pone.0041356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409179/
https://www.ncbi.nlm.nih.gov/pubmed/22859977
http://dx.doi.org/10.1371/journal.pone.0041356

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