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Effects of Niacin Restriction on Sirtuin and PARP Responses to Photodamage in Human Skin
Sirtuins (SIRTs) and poly(ADP-ribose) polymerases (PARPs), NAD(+)-dependent enzymes, link cellular energy status with responses to environmental stresses. Skin is frequently exposed to the DNA damaging effects of UV irradiation, a known etiology in skin cancer. Thus, understanding the defense mechan...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409181/ https://www.ncbi.nlm.nih.gov/pubmed/22860104 http://dx.doi.org/10.1371/journal.pone.0042276 |