Crystal Structure of TNF-α-Inducing Protein from Helicobacter Pylori in Active Form Reveals the Intrinsic Molecular Flexibility for Unique DNA-Binding

Tipα (TNF-α-inducing protein) from Helicobacter pylori is a carcinogenic effector. Studies on this protein revealed that a homodimer linked by a pair of intermolecular disulfide bridges (Cys25-Cys25 and Cys27-Cys27) was absolutely necessary for its biological functions. The activities of Tipα would...

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Detalles Bibliográficos
Autores principales: Gao, Mingming, Li, Defeng, Hu, Yonglin, Zhang, Ying, Zou, Quanming, Wang, Da-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409205/
https://www.ncbi.nlm.nih.gov/pubmed/22860022
http://dx.doi.org/10.1371/journal.pone.0041871

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409205/
https://www.ncbi.nlm.nih.gov/pubmed/22860022
http://dx.doi.org/10.1371/journal.pone.0041871

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