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Local Arginase Inhibition during Early Reperfusion Mediates Cardioprotection via Increased Nitric Oxide Production
Consumption of L-arginine contributes to reduced bioavailability of nitric oxide (NO) that is critical for the development of ischemia-reperfusion injury. The aim of the study was to determine myocardial arginase expression and activity in ischemic-reperfusion myocardium and whether local inhibition...
Autores principales: | Gonon, Adrian T., Jung, Christian, Katz, Abram, Westerblad, Håkan, Shemyakin, Alexey, Sjöquist, Per-Ove, Lundberg, Jon O., Pernow, John |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409239/ https://www.ncbi.nlm.nih.gov/pubmed/22860052 http://dx.doi.org/10.1371/journal.pone.0042038 |
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