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Rational Identification of Enoxacin as a Novel V-ATPase-Directed Osteoclast Inhibitor
Binding between vacuolar H(+)-ATPases (V-ATPases) and microfilaments is mediated by an actin binding domain in the B-subunit. Both isoforms of mammalian B-subunit bind microfilaments with high affinity. A similar actin-binding activity has been demonstrated in the B-subunit of yeast. A conserved “pr...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Bentham Science Publishers
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409362/ https://www.ncbi.nlm.nih.gov/pubmed/22044158 http://dx.doi.org/10.2174/138920312800493151 |