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Rational Identification of Enoxacin as a Novel V-ATPase-Directed Osteoclast Inhibitor

Binding between vacuolar H(+)-ATPases (V-ATPases) and microfilaments is mediated by an actin binding domain in the B-subunit. Both isoforms of mammalian B-subunit bind microfilaments with high affinity. A similar actin-binding activity has been demonstrated in the B-subunit of yeast. A conserved “pr...

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Detalles Bibliográficos
Autores principales:	Toro, Edgardo J, Ostrov, David A, Wronski, Thomas J, Holliday, L Shannon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bentham Science Publishers 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409362/ https://www.ncbi.nlm.nih.gov/pubmed/22044158 http://dx.doi.org/10.2174/138920312800493151

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