Lefty Blocks a Subset of TGFβ Signals by Antagonizing EGF-CFC Coreceptors

Members of the EGF-CFC family play essential roles in embryonic development and have been implicated in tumorigenesis. The TGFβ signals Nodal and Vg1/GDF1, but not Activin, require EGF-CFC coreceptors to activate Activin receptors. We report that the TGFβ signaling antagonist Lefty also acts through...

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Detalles Bibliográficos
Autores principales: Cheng, Simon K, Olale, Felix, Brivanlou, Ali H, Schier, Alexander F
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2004
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC340941/
https://www.ncbi.nlm.nih.gov/pubmed/14966532
http://dx.doi.org/10.1371/journal.pbio.0020030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC340941/
https://www.ncbi.nlm.nih.gov/pubmed/14966532
http://dx.doi.org/10.1371/journal.pbio.0020030

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