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Lefty Blocks a Subset of TGFβ Signals by Antagonizing EGF-CFC Coreceptors
Members of the EGF-CFC family play essential roles in embryonic development and have been implicated in tumorigenesis. The TGFβ signals Nodal and Vg1/GDF1, but not Activin, require EGF-CFC coreceptors to activate Activin receptors. We report that the TGFβ signaling antagonist Lefty also acts through...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2004
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC340941/ https://www.ncbi.nlm.nih.gov/pubmed/14966532 http://dx.doi.org/10.1371/journal.pbio.0020030 |