Engineered Biosynthesis of Regioselectively Modified Aromatic Polyketides Using Bimodular Polyketide Synthases

Bacterial aromatic polyketides such as tetracycline and doxorubicin are a medicinally important class of natural products produced as secondary metabolites by actinomyces bacteria. Their backbones are derived from malonyl-CoA units by polyketide synthases (PKSs). The nascent polyketide chain is synt...

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Detalles Bibliográficos
Autores principales: Tang, Yi, Lee, Taek Soon, Khosla, Chaitan
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2004
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC340942/
https://www.ncbi.nlm.nih.gov/pubmed/14966533
http://dx.doi.org/10.1371/journal.pbio.0020031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC340942/
https://www.ncbi.nlm.nih.gov/pubmed/14966533
http://dx.doi.org/10.1371/journal.pbio.0020031

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