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CENP-E–dependent BubR1 autophosphorylation enhances chromosome alignment and the mitotic checkpoint

How the state of spindle microtubule capture at the kinetochore is translated into mitotic checkpoint signaling remains largely unknown. In this paper, we demonstrate that the kinetochore-associated mitotic kinase BubR1 phosphorylates itself in human cells and that this autophosphorylation is depend...

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Detalles Bibliográficos
Autores principales: Guo, Yige, Kim, Christine, Ahmad, Sana, Zhang, Jiayin, Mao, Yinghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410423/
https://www.ncbi.nlm.nih.gov/pubmed/22801780
http://dx.doi.org/10.1083/jcb.201202152