c-Src-dependent EGF receptor transactivation contributes to ET-1-induced COX-2 expression in brain microvascular endothelial cells

BACKGROUND: Endothelin-1 (ET-1) is elevated and participates in the regulation of several brain inflammatory disorders. The deleterious effects of ET-1 on endothelial cells may aggravate brain inflammation mediated through the upregulation of cyclooxygenase-2 (COX-2) gene expression. However, the si...

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Detalles Bibliográficos
Autores principales: Hsieh, Hsi-Lung, Lin, Chih-Chung, Chan, Hui-Ju, Yang, Caleb M, Yang, Chuen-Mao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410791/
https://www.ncbi.nlm.nih.gov/pubmed/22747786
http://dx.doi.org/10.1186/1742-2094-9-152

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410791/
https://www.ncbi.nlm.nih.gov/pubmed/22747786
http://dx.doi.org/10.1186/1742-2094-9-152

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