Lipopolysaccharide impairs amyloid beta efflux from brain: altered vascular sequestration, cerebrospinal fluid reabsorption, peripheral clearance and transporter function at the blood–brain barrier

BACKGROUND: Defects in the low density lipoprotein receptor-related protein-1 (LRP-1) and p-glycoprotein (Pgp) clearance of amyloid beta (Aβ) from brain are thought to contribute to Alzheimer’s disease (AD). We have recently shown that induction of systemic inflammation by lipopolysaccharide (LPS) r...

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Detalles Bibliográficos
Autores principales: Erickson, Michelle A, Hartvigson, Pehr E, Morofuji, Yoichi, Owen, Joshua B, Butterfield, D Allan, Banks, William A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410805/
https://www.ncbi.nlm.nih.gov/pubmed/22747709
http://dx.doi.org/10.1186/1742-2094-9-150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410805/
https://www.ncbi.nlm.nih.gov/pubmed/22747709
http://dx.doi.org/10.1186/1742-2094-9-150

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