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UNC-40/DCC, SAX-3/Robo, and VAB-1/Eph Polarize F-Actin during Embryonic Morphogenesis by Regulating the WAVE/SCAR Actin Nucleation Complex

Many cells in a developing embryo, including neurons and their axons and growth cones, must integrate multiple guidance cues to undergo directed growth and migration. The UNC-6/netrin, SLT-1/slit, and VAB-2/Ephrin guidance cues, and their receptors, UNC-40/DCC, SAX-3/Robo, and VAB-1/Eph, are known t...

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Detalles Bibliográficos
Autores principales: Bernadskaya, Yelena Y., Wallace, Andre, Nguyen, Jillian, Mohler, William A., Soto, Martha C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410845/
https://www.ncbi.nlm.nih.gov/pubmed/22876199
http://dx.doi.org/10.1371/journal.pgen.1002863