The Role of Local Backrub Motions in Evolved and Designed Mutations

Amino acid substitutions in protein structures often require subtle backbone adjustments that are difficult to model in atomic detail. An improved ability to predict realistic backbone changes in response to engineered mutations would be of great utility for the blossoming field of rational protein...

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Detalles Bibliográficos
Autores principales: Keedy, Daniel A., Georgiev, Ivelin, Triplett, Edward B., Donald, Bruce R., Richardson, David C., Richardson, Jane S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410847/
https://www.ncbi.nlm.nih.gov/pubmed/22876172
http://dx.doi.org/10.1371/journal.pcbi.1002629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410847/
https://www.ncbi.nlm.nih.gov/pubmed/22876172
http://dx.doi.org/10.1371/journal.pcbi.1002629

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