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The Role of Local Backrub Motions in Evolved and Designed Mutations
Amino acid substitutions in protein structures often require subtle backbone adjustments that are difficult to model in atomic detail. An improved ability to predict realistic backbone changes in response to engineered mutations would be of great utility for the blossoming field of rational protein...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410847/ https://www.ncbi.nlm.nih.gov/pubmed/22876172 http://dx.doi.org/10.1371/journal.pcbi.1002629 |