Cargando…

A Positive Feedback Loop Links Opposing Functions of P-TEFb/Cdk9 and Histone H2B Ubiquitylation to Regulate Transcript Elongation in Fission Yeast

Transcript elongation by RNA polymerase II (RNAPII) is accompanied by conserved patterns of histone modification. Whereas histone modifications have established roles in transcription initiation, their functions during elongation are not understood. Mono-ubiquitylation of histone H2B (H2Bub1) plays...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sansó, Miriam, Lee, Karen M., Viladevall, Laia, Jacques, Pierre-Étienne, Pagé, Viviane, Nagy, Stephen, Racine, Ariane, St. Amour, Courtney V., Zhang, Chao, Shokat, Kevan M., Schwer, Beate, Robert, François, Fisher, Robert P., Tanny, Jason C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410854/ https://www.ncbi.nlm.nih.gov/pubmed/22876190 http://dx.doi.org/10.1371/journal.pgen.1002822

Ejemplares similares

The PAF Complex and Prf1/Rtf1 Delineate Distinct Cdk9-Dependent Pathways Regulating Transcription Elongation in Fission Yeast
por: Mbogning, Jean, et al.
Publicado: (2013)

P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates
por: Sansó, Miriam, et al.
Publicado: (2016)

Cdk9 regulates a promoter-proximal checkpoint to modulate RNA polymerase II elongation rate in fission yeast
por: Booth, Gregory T., et al.
Publicado: (2018)

A Cdk9-PP1 switch regulates the elongation-termination transition of RNA polymerase II
por: Parua, Pabitra K., et al.
Publicado: (2018)

Decoding histone ubiquitylation
por: Chen, Jennifer J., et al.
Publicado: (2022)

Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II
por: Larochelle, Stéphane, et al.
Publicado: (2012)

Distinct Cdk9-phosphatase switches act at the beginning and end of elongation by RNA polymerase II
por: Parua, Pabitra K., et al.
Publicado: (2020)

Ikaros interacts with P-TEFb and cooperates with GATA-1 to enhance transcription elongation
por: Bottardi, Stefania, et al.
Publicado: (2011)

Positive transcription elongation factor b (P-TEFb) is a therapeutic target in human multiple myeloma
por: Zhang, Yu, et al.
Publicado: (2017)

Cdk9 and H2Bub1 signal to Clr6-CII/Rpd3S to suppress aberrant antisense transcription
por: Sansó, Miriam, et al.
Publicado: (2020)

Cracking the control of RNA polymerase II elongation by 7SK snRNP and P-TEFb
por: C. Quaresma, Alexandre J., et al.
Publicado: (2016)

The CDK Pef1 and protein phosphatase 4 oppose each other for regulating cohesin binding to fission yeast chromosomes
por: Birot, Adrien, et al.
Publicado: (2020)

TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb
por: Ma, Xiancai, et al.
Publicado: (2019)

Targeting CDK9 and MCL-1 by a new CDK9/p-TEFb inhibitor with and without 5-fluorouracil in esophageal adenocarcinoma
por: Tong, Zhimin, et al.
Publicado: (2019)

SAT-037 Functional Interplay between Distinct P-TEFb Complexes Following Endothelin or α(1)-Adrenergic Receptor Activation in Rat Cardiomyocytes
por: Martin, Ryan, et al.
Publicado: (2019)

ZASC1 Stimulates HIV-1 Transcription Elongation by Recruiting P-TEFb and TAT to the LTR Promoter
por: Bruce, James W., et al.
Publicado: (2013)

Functional interaction of Rpb1 and Spt5 C-terminal domains in co-transcriptional histone modification
por: Mbogning, Jean, et al.
Publicado: (2015)

PCNA ubiquitylation ensures timely completion of unperturbed DNA replication in fission yeast
por: Daigaku, Yasukazu, et al.
Publicado: (2017)

P-TEFb- the final frontier
por: Kohoutek, Jiri
Publicado: (2009)

P‐TEFb goes viral
por: Zaborowska, Justyna, et al.
Publicado: (2015)

AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter
por: Schulze-Gahmen, Ursula, et al.
Publicado: (2014)

JMJD6 cleaves MePCE to release positive transcription elongation factor b (P-TEFb) in higher eukaryotes
por: Lee, Schuyler, et al.
Publicado: (2020)

BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation
por: Campagne, Antoine, et al.
Publicado: (2019)

Inhibition of CDK12 elevates cancer cell dependence on P-TEFb by stimulation of RNA polymerase II pause release
por: Wang, Zhijia, et al.
Publicado: (2023)

Polo-Like Kinase 1 Inhibits the Activity of Positive Transcription Elongation Factor of RNA Pol II b (P-TEFb)
por: Jiang, Liangzhen, et al.
Publicado: (2013)

Making a Short Story Long: Regulation of P-TEFb and HIV-1 Transcriptional Elongation in CD4(+) T Lymphocytes and Macrophages
por: Ramakrishnan, Rajesh, et al.
Publicado: (2012)

RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation
por: Guturi, Kiran Kumar Naidu, et al.
Publicado: (2016)

Megakaryocytic irreversible P-TEFb activation
por: Elagib, Kamaleldin E, et al.
Publicado: (2014)

Phosphorylation of CDK9 at Ser175 Enhances HIV Transcription and Is a Marker of Activated P-TEFb in CD4(+) T Lymphocytes
por: Mbonye, Uri R., et al.
Publicado: (2013)

P-TEFb, the Super Elongation Complex and Mediator Regulate a Subset of Non-paused Genes during Early Drosophila Embryo Development
por: Dahlberg, Olle, et al.
Publicado: (2015)

A Cyclin T1 point mutation that abolishes positive transcription elongation factor (P-TEFb) binding to Hexim1 and HIV tat
por: Verstraete, Nina, et al.
Publicado: (2014)

Transcription elongation factor Brd4-P-TEFb accelerates intestinal differentiation-associated SLC2A5 gene expression
por: Inamochi, Yuko, et al.
Publicado: (2016)

The CDK9/Cyclin T1 subunits of P-TEFb in mouse oocytes and preimplantation embryos: A possible role in embryonic genome activation
por: Oqani, Reza K, et al.
Publicado: (2011)

Chemical Genetics Reveals a Specific Requirement for Cdk2 Activity in the DNA Damage Response and Identifies Nbs1 as a Cdk2 Substrate in Human Cells
por: Wohlbold, Lara, et al.
Publicado: (2012)

P-TEFb as A Promising Therapeutic Target
por: Fujinaga, Koh
Publicado: (2020)

Correction: P-TEFb, the Super Elongation Complex and Mediator Regulate a Subset of Non-paused Genes during Early Drosophila Embryo Development
Publicado: (2015)

The chaperone protein p32 stabilizes HIV-1 Tat and strengthens the p-TEFb/RNAPII/TAR complex promoting HIV transcription elongation
por: Li, Chuan, et al.
Publicado: (2022)

Opposing effects of trans‐ and cis‐cinnamic acid during rice coleoptile elongation
por: Vlaminck, Lena, et al.
Publicado: (2022)

Opposing functions of the Hda1 complex and histone H2B mono-ubiquitylation in regulating cryptic transcription in Saccharomyces cerevisiae
por: Shirra, Margaret K, et al.
Publicado: (2021)

Manipulation of P-TEFb control machinery by HIV: recruitment of P-TEFb from the large form by Tat and binding of HEXIM1 to TAR
por: Sedore, Stanley C., et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_189f0ef7m8afkpu14ccs1j0akm