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Molecular Constraints on Synaptic Tagging and Maintenance of Long-Term Potentiation: A Predictive Model

Protein synthesis-dependent, late long-term potentiation (LTP) and depression (LTD) at glutamatergic hippocampal synapses are well characterized examples of long-term synaptic plasticity. Persistent increased activity of protein kinase M ζ (PKMζ) is thought essential for maintaining LTP. Additional...

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Detalles Bibliográficos
Autores principales: Smolen, Paul, Baxter, Douglas A., Byrne, John H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410876/
https://www.ncbi.nlm.nih.gov/pubmed/22876169
http://dx.doi.org/10.1371/journal.pcbi.1002620