6-Arylpyrido[2,3-d]pyrimidines as Novel ATP-Competitive Inhibitors of Bacterial D-Alanine:D-Alanine Ligase

BACKGROUND: ATP-dependent D-alanine:D-alanine ligase (Ddl) is a part of biochemical machinery involved in peptidoglycan biosynthesis, as it catalyzes the formation of the terminal D-ala-D-ala dipeptide of the peptidoglycan precursor UDPMurNAc-pentapeptide. Inhibition of Ddl prevents bacterial growth...

Descripción completa

Detalles Bibliográficos
Autores principales: Škedelj, Veronika, Arsovska, Emilija, Tomašić, Tihomir, Kroflič, Ana, Hodnik, Vesna, Hrast, Martina, Bešter-Rogač, Marija, Anderluh, Gregor, Gobec, Stanislav, Bostock, Julieanne, Chopra, Ian, O'Neill, Alex J., Randall, Christopher, Zega, Anamarija
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410885/
https://www.ncbi.nlm.nih.gov/pubmed/22876277
http://dx.doi.org/10.1371/journal.pone.0039922

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410885/
https://www.ncbi.nlm.nih.gov/pubmed/22876277
http://dx.doi.org/10.1371/journal.pone.0039922

Ejemplares similares