Nras Overexpression Results in Granulocytosis, T-Cell Expansion and Early Lethality in Mice

NRAS is a proto-oncogene involved in numerous myeloid malignancies. Here, we report on a mouse line bearing a single retroviral long terminal repeat inserted into Nras. This genetic modification resulted in an increased level of wild type Nras mRNA giving the possibility of studying the function and...

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Detalles Bibliográficos
Autores principales: Lassen, Louise Berkhoudt, Ballarín-González, Borja, Schmitz, Alexander, Füchtbauer, Annette, Pedersen, Finn Skou, Füchtbauer, Ernst-Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410918/
https://www.ncbi.nlm.nih.gov/pubmed/22876308
http://dx.doi.org/10.1371/journal.pone.0042216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410918/
https://www.ncbi.nlm.nih.gov/pubmed/22876308
http://dx.doi.org/10.1371/journal.pone.0042216

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