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Metabolic and thermal stimuli control K(2P)2.1 (TREK-1) through modular sensory and gating domains
K(2P)2.1 (TREK-1) is a polymodal two-pore domain leak potassium channel that responds to external pH, GPCR-mediated phosphorylation signals, and temperature through the action of distinct sensors within the channel. How the various intracellular and extracellular sensory elements control channel fun...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
European Molecular Biology Organization
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411076/ https://www.ncbi.nlm.nih.gov/pubmed/22728824 http://dx.doi.org/10.1038/emboj.2012.171 |