Drosophila larvae lacking the bcl-2 gene, buffy, are sensitive to nutrient stress, maintain increased basal target of rapamycin (Tor) signaling and exhibit characteristics of altered basal energy metabolism

BACKGROUND: B cell lymphoma 2 (Bcl-2) proteins are the central regulators of apoptosis. The two bcl-2 genes in Drosophila modulate the response to stress-induced cell death, but not developmental cell death. Because null mutants are viable, Drosophila provides an optimum model system to investigate...

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Detalles Bibliográficos
Autores principales: Monserrate, Jessica P, Chen, Michelle Y-Y, Brachmann, Carrie Baker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411425/
https://www.ncbi.nlm.nih.gov/pubmed/22824239
http://dx.doi.org/10.1186/1741-7007-10-63

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411425/
https://www.ncbi.nlm.nih.gov/pubmed/22824239
http://dx.doi.org/10.1186/1741-7007-10-63

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