Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity

BACKGROUND: Nor-BNI, GNTI and JDTic induce κ opioid antagonism that is delayed by hours and can persist for months. Other effects are transient. It has been proposed that these drugs may be slowly absorbed or distributed, and may dissolve in cell membranes, thus slowing elimination and prolonging th...

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Detalles Bibliográficos
Autores principales: Munro, Thomas A, Berry, Loren M, Van’t Veer, Ashlee, Béguin, Cécile, Carroll, F Ivy, Zhao, Zhiyang, Carlezon, William A, Cohen, Bruce M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411462/
https://www.ncbi.nlm.nih.gov/pubmed/22642416
http://dx.doi.org/10.1186/1471-2210-12-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411462/
https://www.ncbi.nlm.nih.gov/pubmed/22642416
http://dx.doi.org/10.1186/1471-2210-12-5

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