Crucial Role of TSC-22 in Preventing the Proteasomal Degradation of p53 in Cervical Cancer

The p53 tumor suppressor function can be compromised in many tumors by the cellular antagonist HDM2 and human papillomavirus oncogene E6 that induce p53 degradation. Restoration of p53 activity has strong therapeutic potential. Here, we identified TSC-22 as a novel p53-interacting protein and show i...

Descripción completa

Detalles Bibliográficos
Autores principales: Yoon, Cheol-Hee, Rho, Seung Bae, Kim, Seong-Tae, Kho, Seongho, Park, Junsoo, Jang, Ik-Soon, Woo, Seonock, Kim, Sung Soon, Lee, Je-Ho, Lee, Seung-Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411576/
https://www.ncbi.nlm.nih.gov/pubmed/22870275
http://dx.doi.org/10.1371/journal.pone.0042006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411576/
https://www.ncbi.nlm.nih.gov/pubmed/22870275
http://dx.doi.org/10.1371/journal.pone.0042006

Ejemplares similares