MicroRNA-34a Modulates MDM4 Expression via a Target Site in the Open Reading Frame

BACKGROUND: MDM4, also called MDMX or HDMX in humans, is an important negative regulator of the p53 tumor suppressor. MDM4 is overexpressed in about 17% of all cancers and more frequently in some types, such as colon cancer or retinoblastoma. MDM4 is known to be post-translationally regulated by MDM...

Descripción completa

Detalles Bibliográficos
Autores principales: Mandke, Pooja, Wyatt, Nicholas, Fraser, Jillian, Bates, Benjamin, Berberich, Steven J., Markey, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411609/
https://www.ncbi.nlm.nih.gov/pubmed/22870278
http://dx.doi.org/10.1371/journal.pone.0042034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411609/
https://www.ncbi.nlm.nih.gov/pubmed/22870278
http://dx.doi.org/10.1371/journal.pone.0042034

Ejemplares similares