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MicroRNA-34a Modulates MDM4 Expression via a Target Site in the Open Reading Frame
BACKGROUND: MDM4, also called MDMX or HDMX in humans, is an important negative regulator of the p53 tumor suppressor. MDM4 is overexpressed in about 17% of all cancers and more frequently in some types, such as colon cancer or retinoblastoma. MDM4 is known to be post-translationally regulated by MDM...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411609/ https://www.ncbi.nlm.nih.gov/pubmed/22870278 http://dx.doi.org/10.1371/journal.pone.0042034 |