Isoform-Specific Dominant-Negative Effects Associated with hERG1 G628S Mutation in Long QT Syndrome

BACKGROUND: Mutations in the human ether-a-go-go-related gene 1 (hERG1) cause type 2 long QT syndrome (LQT2). The hERG1 gene encodes a K(+) channel with properties similar to the rapidly activating delayed rectifying K(+) current in the heart. Several hERG1 isoforms with unique structural and functi...

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Detalles Bibliográficos
Autores principales: Stump, Matthew R., Gong, Qiuming, Zhou, Zhengfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411645/
https://www.ncbi.nlm.nih.gov/pubmed/22876326
http://dx.doi.org/10.1371/journal.pone.0042552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411645/
https://www.ncbi.nlm.nih.gov/pubmed/22876326
http://dx.doi.org/10.1371/journal.pone.0042552

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