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Novel Nuclear Localization and Potential Function of Insulin-Like Growth Factor-1 Receptor/Insulin Receptor Hybrid in Corneal Epithelial Cells

BACKGROUND: Type I insulin-like growth factor receptor (IGF-1R) and insulin receptor (INSR) are highly homologous molecules, which can heterodimerize to form an IGF-1R/INSR hybrid (Hybrid-R). The presence and biological significance of the Hybrid-R in human corneal epithelium has not yet been establ...

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Detalles Bibliográficos
Autores principales: Wu, Yu-Chieh, Zhu, Meifang, Robertson, Danielle M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411736/
https://www.ncbi.nlm.nih.gov/pubmed/22879999
http://dx.doi.org/10.1371/journal.pone.0042483