Cargando…

Novel Nuclear Localization and Potential Function of Insulin-Like Growth Factor-1 Receptor/Insulin Receptor Hybrid in Corneal Epithelial Cells

BACKGROUND: Type I insulin-like growth factor receptor (IGF-1R) and insulin receptor (INSR) are highly homologous molecules, which can heterodimerize to form an IGF-1R/INSR hybrid (Hybrid-R). The presence and biological significance of the Hybrid-R in human corneal epithelium has not yet been establ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Yu-Chieh, Zhu, Meifang, Robertson, Danielle M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411736/ https://www.ncbi.nlm.nih.gov/pubmed/22879999 http://dx.doi.org/10.1371/journal.pone.0042483

Ejemplares similares

Insulin mediates de novo nuclear accumulation of the IGF-1/insulin Hybrid Receptor in corneal epithelial cells
por: Titone, Rossella, et al.
Publicado: (2018)

How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor
por: Xu, Yibin, et al.
Publicado: (2022)

Two-Tiered Control of Epithelial Growth and Autophagy by the Insulin Receptor and the Ret-Like Receptor, Stitcher
por: O'Farrell, Fergal, et al.
Publicado: (2013)

Deciphering Brain Insulin Receptor and Insulin‐Like Growth Factor 1 Receptor Signalling
por: Kleinridders, A.
Publicado: (2016)

The effect of insulin on equine lamellar basal epithelial cells mediated by the insulin-like growth factor-1 receptor
por: Baskerville, Courtnay L., et al.
Publicado: (2018)

Insulin, insulin-like growth factor–1, insulin receptor, and insulin-like growth factor–1 receptor expression in the chick eye and their regulation with imposed myopic or hyperopic defocus
por: Penha, Alexandra Marcha, et al.
Publicado: (2011)

Role of Insulin-like Growth Factor, Insulin-like Growth Factor Receptors, and Insulin-like Growth Factor-binding Proteins in Ovarian Cancer
por: Amutha, Periyasamy, et al.
Publicado: (2017)

Insulin and insulin like growth factor II endocytosis and signaling via insulin receptor B
por: Giudice, Jimena, et al.
Publicado: (2013)

Quantitative analysis of insulin-like growth factor 2 receptor and insulin-like growth factor binding proteins to identify control mechanisms for insulin-like growth factor 1 receptor phosphorylation
por: Tian, Dan, et al.
Publicado: (2016)

Insulin Receptor Isoforms and Insulin Growth Factor-like Receptors: Implications in Cell Signaling, Carcinogenesis, and Chemoresistance
por: Galal, Mariam Ahmed, et al.
Publicado: (2023)

Combined and individual tumor-specific expression of insulin-like growth factor-I receptor, insulin receptor and phospho-insulin-like growth factor-I receptor/insulin receptor in primary breast cancer: Implications for prognosis in different treatment groups
por: Björner, Sofie, et al.
Publicado: (2016)

Ligand-Mediated Endocytosis and Trafficking of the Insulin-Like Growth Factor Receptor I and Insulin Receptor Modulate Receptor Function
por: Morcavallo, Alaide, et al.
Publicado: (2014)

Effects of obesity on insulin: insulin-like growth factor 1 hybrid receptor expression and Akt phosphorylation in conduit and resistance arteries
por: Mughal, Romana S, et al.
Publicado: (2018)

Differential roles of insulin like growth factor 1 receptor and insulin receptor during embryonic heart development
por: Wang, Kai, et al.
Publicado: (2019)

Insulin-like growth factor-2 regulates basal retinal insulin receptor activity
por: Zolov, Sergey N., et al.
Publicado: (2021)

A versatile insulin analog with high potency for both insulin and insulin-like growth factor 1 receptors: Structural implications for receptor binding
por: Chrudinová, Martina, et al.
Publicado: (2018)

The insulin-like growth factor system and its receptors: A potential novel anticancer target
por: Lindsay, Colin R, et al.
Publicado: (2008)

erbB3 recruitment of insulin receptor substrate 1 modulates insulin-like growth factor receptor signalling in oestrogen receptor-positive breast cancer cell lines
por: Knowlden, Janice M, et al.
Publicado: (2011)

Targeting Insulin and Insulin-Like Growth Factor Pathways in Epithelial Ovarian Cancer
por: Beauchamp, Marie-Claude, et al.
Publicado: (2010)

Insulin-Like Growth Factor Binding Protein-6 Promotes the Differentiation of Placental Mesenchymal Stem Cells into Skeletal Muscle Independent of Insulin-Like Growth Factor Receptor-1 and Insulin Receptor
por: Aboalola, Doaa, et al.
Publicado: (2019)

Understanding the Mechanism of Insulin and Insulin-Like Growth Factor (IGF) Receptor Activation by IGF-II
por: Alvino, Clair L., et al.
Publicado: (2011)

Insulin-like growth factors: Ligands, binding proteins, and receptors
por: LeRoith, Derek, et al.
Publicado: (2021)

Glycan Modulation of Insulin‐like Growth Factor‐1 Receptor
por: Boothello, Rio S., et al.
Publicado: (2022)

Insulin receptor substrates mediate distinct biological responses to insulin-like growth factor receptor activation in breast cancer cells
por: Byron, S A, et al.
Publicado: (2006)

Molecular basis for the role of disulfide-linked αCTs in the activation of insulin-like growth factor 1 receptor and insulin receptor
por: Li, Jie, et al.
Publicado: (2022)

Type 1 Insulin-Like Growth Factor Receptor Nuclear Localization in High-Grade Glioma Cells Enhances Motility, Metabolism, and In Vivo Tumorigenesis
por: Martin, Ayelen, et al.
Publicado: (2022)

Insulin and insulin-like growth factor-I receptors in astrocytes exert different effects on behavior and Alzheimer´s-like pathology
por: Zegarra-Valdivia, Jonathan, et al.
Publicado: (2022)

Role of insulin-like growth factor 1 receptor signalling in cancer
por: Larsson, O, et al.
Publicado: (2005)

Targeting the insulin-like growth factor-1 receptor in human cancer
por: Arcaro, Alexandre
Publicado: (2013)

Insulin growth factor 1 like receptor (IGF-1R)
por: Iyer, Gopal, et al.
Publicado: (2016)

Insulin-like growth factor 1 receptor mediates photoreceptor neuroprotection
por: Rajala, Ammaji, et al.
Publicado: (2022)

Targeting Non-Small Cell Lung Cancer Cells by Dual Inhibition of the Insulin Receptor and the Insulin-Like Growth Factor-1 Receptor
por: Vincent, Emma E., et al.
Publicado: (2013)

The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/insulin-like growth factor receptor signaling
por: Gayen, Manoshi, et al.
Publicado: (2022)

The roles of glucagon-like peptide-2 and the intestinal epithelial insulin-like growth factor-1 receptor in regulating microvillus length
por: Markovic, Melanie A., et al.
Publicado: (2019)

Direct integrin binding to insulin-like growth factor-2 through the C-domain is required for insulin-like growth factor receptor type 1 (IGF1R) signaling
por: Cedano Prieto, Dora Maria, et al.
Publicado: (2017)

The IGF/Insulin-IGFBP Axis in Corneal Development, Wound Healing, and Disease
por: Stuard, Whitney L., et al.
Publicado: (2020)

A Hepatocyte Growth Factor Receptor (Met)–Insulin Receptor hybrid governs hepatic glucose metabolism
por: Fafalios, Arlee, et al.
Publicado: (2011)

Statins inhibit insulin-like growth factor action in first trimester placenta by altering insulin-like growth factor 1 receptor glycosylation
por: Forbes, Karen, et al.
Publicado: (2015)

All-Atom Structural Models of the Transmembrane Domains of Insulin and Type 1 Insulin-Like Growth Factor Receptors
por: Mohammadiarani, Hossein, et al.
Publicado: (2016)

Acute Modulation of Toll-Like Receptors by Insulin
por: Ghanim, Husam, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_ljie2lcp9re7p8t4u4cleccq9h