c-Abl Is an Upstream Regulator of Acid Sphingomyelinase in Apoptosis Induced by Inhibition of Integrins αvβ3 and αvβ5

Inhibition of integrins αvβ3/αvβ5 by the cyclic function-blocking peptide, RGDfV (Arg-Gly-Asp-Phe-Val) can induce apoptosis in both normal cells and tumor cells. We show that RGDfV induced apoptosis in ECV-304 carcinoma cells, increased activity and mRNA expression of acid sphingomyelinase (ASM), an...

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Detalles Bibliográficos
Autores principales: Ren, Xiuhai, Xu, Jingying, Cooper, Jason P., Kang, Min H., Erdreich-Epstein, Anat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411766/
https://www.ncbi.nlm.nih.gov/pubmed/22879933
http://dx.doi.org/10.1371/journal.pone.0042291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411766/
https://www.ncbi.nlm.nih.gov/pubmed/22879933
http://dx.doi.org/10.1371/journal.pone.0042291

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