TGFβ-Stimulated MicroRNA-21 Utilizes PTEN to Orchestrate AKT/mTORC1 Signaling for Mesangial Cell Hypertrophy and Matrix Expansion

Transforming growth factor-β (TGFβ) promotes glomerular hypertrophy and matrix expansion, leading to glomerulosclerosis. MicroRNAs are well suited to promote fibrosis because they can repress gene expression, which negatively regulate the fibrotic process. Recent cellular and animal studies have rev...

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Detalles Bibliográficos
Autores principales: Dey, Nirmalya, Ghosh-Choudhury, Nandini, Kasinath, Balakuntalam S., Choudhury, Goutam Ghosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411779/
https://www.ncbi.nlm.nih.gov/pubmed/22879939
http://dx.doi.org/10.1371/journal.pone.0042316

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411779/
https://www.ncbi.nlm.nih.gov/pubmed/22879939
http://dx.doi.org/10.1371/journal.pone.0042316

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