High Basal Activity of the PTPN22 Gain-of-Function Variant Blunts Leukocyte Responsiveness Negatively Affecting IL-10 Production in ANCA Vasculitis

Consequences of expression of the protein tyrosine phosphatase nonreceptor 22 (PTPN22) gain-of-function variant were evaluated in leukocytes from patients with anti-neutrophil cytoplasmic autoantibody (ANCA) disease. The frequency of the gain-of-function allele within the Caucasian patient cohort wa...

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Detalles Bibliográficos
Autores principales: Cao, Yali, Yang, Jiajin, Colby, Kerry, Hogan, Susan L., Hu, Yichun, Jennette, Caroline E., Berg, Elisabeth A., Zhang, Youkang, Jennette, J. Charles, Falk, Ronald J., Preston, Gloria A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411839/
https://www.ncbi.nlm.nih.gov/pubmed/22880107
http://dx.doi.org/10.1371/journal.pone.0042783

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411839/
https://www.ncbi.nlm.nih.gov/pubmed/22880107
http://dx.doi.org/10.1371/journal.pone.0042783

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