Single-Channel Electrophysiology Reveals a Distinct and Uniform Pore Complex Formed by α-Synuclein Oligomers in Lipid Membranes

Synucleinopathies such as Parkinson's disease, multiple system atrophy and dementia with Lewy bodies are characterized by deposition of aggregated α-synuclein. Recent findings indicate that pathological oligomers rather than fibrillar aggregates may represent the main toxic protein species. It...

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Detalles Bibliográficos
Autores principales: Schmidt, Felix, Levin, Johannes, Kamp, Frits, Kretzschmar, Hans, Giese, Armin, Bötzel, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411845/
https://www.ncbi.nlm.nih.gov/pubmed/22880029
http://dx.doi.org/10.1371/journal.pone.0042545

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411845/
https://www.ncbi.nlm.nih.gov/pubmed/22880029
http://dx.doi.org/10.1371/journal.pone.0042545

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