Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

Fatty liver disease is associated with obesity and type 2 diabetes, and hepatic lipid accumulation may contribute to insulin resistance by a variety of mechanisms. Here we show that mice with liver-specific deletion of histone deacetylase 3 (Hdac3) display severe hepatosteatosis and, notably increas...

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Detalles Bibliográficos
Autores principales: Sun, Zheng, Miller, Russell A., Patel, Rajesh T., Chen, Jie, Dhir, Ravindra, Wang, Hong, Zhang, Dongyan, Graham, Mark J., Unterman, Terry G., Shulman, Gerald I., Sztalryd, Carole, Bennett, Michael J., Ahima, Rexford S., Birnbaum, Morris J., Lazar, Mitchell A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411870/
https://www.ncbi.nlm.nih.gov/pubmed/22561686
http://dx.doi.org/10.1038/nm.2744

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411870/
https://www.ncbi.nlm.nih.gov/pubmed/22561686
http://dx.doi.org/10.1038/nm.2744

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