Expanded ataxin-7 cause toxicity by inducing ROS production from NADPH oxidase complexes in a stable inducible Spinocerebellar ataxia type 7 (SCA7) model

BACKGROUND: Spinocerebellar ataxia type 7 (SCA7) is one of nine inherited neurodegenerative disorders caused by polyglutamine (polyQ) expansions. Common mechanisms of disease pathogenesis suggested for polyQ disorders include aggregation of the polyQ protein and induction of oxidative stress. Howeve...

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Detalles Bibliográficos
Autores principales: Ajayi, Abiodun, Yu, Xin, Lindberg, Staffan, Langel, Ülo, Ström, Anna-Lena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412756/
https://www.ncbi.nlm.nih.gov/pubmed/22827889
http://dx.doi.org/10.1186/1471-2202-13-86

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412756/
https://www.ncbi.nlm.nih.gov/pubmed/22827889
http://dx.doi.org/10.1186/1471-2202-13-86

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