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Anomalous dispersion analysis of inhibitor flexibility: a case study of the kinase inhibitor H-89
With its ability to show the interactions between drug-target proteins and small-molecule ligands, X-ray crystallography is an essential tool in drug-discovery programmes. However, its usefulness can be limited by crystallization artifacts or by the data resolution, and in particular when assumption...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
International Union of Crystallography
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412763/ https://www.ncbi.nlm.nih.gov/pubmed/22869112 http://dx.doi.org/10.1107/S1744309112028655 |