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Peptidome Analysis of Cerebrospinal Fluid by LC-MALDI MS

We report on the analysis of endogenous peptides in cerebrospinal fluid (CSF) by mass spectrometry. A method was developed for preparation of peptide extracts from CSF. Analysis of the extracts by offline LC-MALDI MS resulted in the detection of 3,000–4,000 peptide-like features. Out of these, 730 p...

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Detalles Bibliográficos
Autores principales: Hölttä, Mikko, Zetterberg, Henrik, Mirgorodskaya, Ekaterina, Mattsson, Niklas, Blennow, Kaj, Gobom, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412831/
https://www.ncbi.nlm.nih.gov/pubmed/22880031
http://dx.doi.org/10.1371/journal.pone.0042555