COMMD1-Deficient Dogs Accumulate Copper in Hepatocytes and Provide a Good Model for Chronic Hepatitis and Fibrosis

New therapeutic concepts developed in rodent models should ideally be evaluated in large animal models prior to human clinical application. COMMD1-deficiency in dogs leads to hepatic copper accumulation and chronic hepatitis representing a Wilson’s disease like phenotype. Detailed understanding of t...

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Detalles Bibliográficos
Autores principales: Favier, Robert P., Spee, Bart, Schotanus, Baukje A., van den Ingh, Ted S. G. A. M., Fieten, Hille, Brinkhof, Bas, Viebahn, Cornelia S., Penning, Louis C., Rothuizen, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412840/
https://www.ncbi.nlm.nih.gov/pubmed/22879914
http://dx.doi.org/10.1371/journal.pone.0042158

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412840/
https://www.ncbi.nlm.nih.gov/pubmed/22879914
http://dx.doi.org/10.1371/journal.pone.0042158

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