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Identification of high-confidence somatic mutations in whole genome sequence of formalin-fixed breast cancer specimens
The utilization of archived, formalin-fixed paraffin-embedded (FFPE) tumor samples for massive parallel sequencing has been challenging due to DNA damage and contamination with normal stroma. Here, we perform whole genome sequencing of DNA isolated from two triple-negative breast cancer tumors archi...
Autores principales: | Yost, Shawn E., Smith, Erin N., Schwab, Richard B., Bao, Lei, Jung, HyunChul, Wang, Xiaoyun, Voest, Emile, Pierce, John P., Messer, Karen, Parker, Barbara A., Harismendy, Olivier, Frazer, Kelly A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413110/ https://www.ncbi.nlm.nih.gov/pubmed/22492626 http://dx.doi.org/10.1093/nar/gks299 |
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