Oxidative stress during mitochondrial biogenesis compromises mtDNA integrity in growing hearts and induces a global DNA repair response

Cardiomyocyte development in mammals is characterized by a transition from hyperplastic to hypertrophic growth soon after birth. The rise of cardiomyocyte cell mass in postnatal life goes along with a proportionally bigger increase in the mitochondrial mass in response to growing energy requirements...

Descripción completa

Detalles Bibliográficos
Autores principales: Pohjoismäki, Jaakko L. O., Boettger, Thomas, Liu, Zhipei, Goffart, Steffi, Szibor, Marten, Braun, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413112/
https://www.ncbi.nlm.nih.gov/pubmed/22508755
http://dx.doi.org/10.1093/nar/gks301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413112/
https://www.ncbi.nlm.nih.gov/pubmed/22508755
http://dx.doi.org/10.1093/nar/gks301

Ejemplares similares