Structural study of MCPIP1 N-terminal conserved domain reveals a PIN-like RNase

MCP-1-induced protein 1 (MCPIP1) plays an important role in the downregulation of the LPS-induced immune response by acting as an RNase targeting IL-6 and IL-12b mRNAs. A conserved domain located in the N-terminal part of MCPIP1 is thought to be responsible for its RNase activity, but its catalytic...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Jiwei, Peng, Wei, Sun, Yao, Wang, Xiangxi, Xu, Yihui, Li, Xuemei, Gao, Guangxia, Rao, Zihe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413151/
https://www.ncbi.nlm.nih.gov/pubmed/22561375
http://dx.doi.org/10.1093/nar/gks359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413151/
https://www.ncbi.nlm.nih.gov/pubmed/22561375
http://dx.doi.org/10.1093/nar/gks359

Ejemplares similares