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Structural study of MCPIP1 N-terminal conserved domain reveals a PIN-like RNase

MCP-1-induced protein 1 (MCPIP1) plays an important role in the downregulation of the LPS-induced immune response by acting as an RNase targeting IL-6 and IL-12b mRNAs. A conserved domain located in the N-terminal part of MCPIP1 is thought to be responsible for its RNase activity, but its catalytic...

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Detalles Bibliográficos
Autores principales:	Xu, Jiwei, Peng, Wei, Sun, Yao, Wang, Xiangxi, Xu, Yihui, Li, Xuemei, Gao, Guangxia, Rao, Zihe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413151/ https://www.ncbi.nlm.nih.gov/pubmed/22561375 http://dx.doi.org/10.1093/nar/gks359

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