Biochemical analyses indicate that binding and cleavage specificities define the ordered processing of human Okazaki fragments by Dna2 and FEN1

In eukaryotic Okazaki fragment processing, the RNA primer is displaced into a single-stranded flap prior to removal. Evidence suggests that some flaps become long before they are cleaved, and that this cleavage involves the sequential action of two nucleases. Strand displacement characteristics of t...

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Detalles Bibliográficos
Autores principales: Gloor, Jason W., Balakrishnan, Lata, Campbell, Judith L., Bambara, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413157/
https://www.ncbi.nlm.nih.gov/pubmed/22570407
http://dx.doi.org/10.1093/nar/gks388

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413157/
https://www.ncbi.nlm.nih.gov/pubmed/22570407
http://dx.doi.org/10.1093/nar/gks388

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