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Overexpression of human SOD1 improves survival of mice susceptible to endotoxic shock
BACKGROUND: Protective effects of the antioxidant enzyme Cu-Zn superoxide dismutase (SOD1) against endotoxic shock have not been demonstrated in animal models. We used a murine model to investigate whether overexpression of SOD1 protects against endotoxic shock, and whether the genetic background of...
Autores principales: | Charchaflieh, Jean, Labaze, Georges I, Li, Pulsar, Van Remmen, Holly, Lee, Haekyung, Stutz, Helen, Richardson, Arlan, Emanuel, Asher, Zhang, Ming |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413208/ https://www.ncbi.nlm.nih.gov/pubmed/22879777 http://dx.doi.org/10.2147/JIR.S32073 |
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