Hsp70 targets Hsp100 chaperones to substrates for protein disaggregation and prion fragmentation

Hsp100 and Hsp70 chaperones in bacteria, yeast, and plants cooperate to reactivate aggregated proteins. Disaggregation relies on Hsp70 function and on ATP-dependent threading of aggregated polypeptides through the pore of the Hsp100 AAA(+) hexamer. In yeast, both chaperones also promote propagation...

Descripción completa

Detalles Bibliográficos
Autores principales: Winkler, Juliane, Tyedmers, Jens, Bukau, Bernd, Mogk, Axel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413357/
https://www.ncbi.nlm.nih.gov/pubmed/22869599
http://dx.doi.org/10.1083/jcb.201201074

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413357/
https://www.ncbi.nlm.nih.gov/pubmed/22869599
http://dx.doi.org/10.1083/jcb.201201074

Ejemplares similares