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CULLIN-3 Controls TIMELESS Oscillations in the Drosophila Circadian Clock

Eukaryotic circadian clocks rely on transcriptional feedback loops. In Drosophila, the PERIOD (PER) and TIMELESS (TIM) proteins accumulate during the night, inhibit the activity of the CLOCK (CLK)/CYCLE (CYC) transcriptional complex, and are degraded in the early morning. The control of PER and TIM...

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Detalles Bibliográficos
Autores principales: Grima, Brigitte, Dognon, Alexandre, Lamouroux, Annie, Chélot, Elisabeth, Rouyer, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413713/
https://www.ncbi.nlm.nih.gov/pubmed/22879814
http://dx.doi.org/10.1371/journal.pbio.1001367