Cyclic RGD peptide-modified liposomal drug delivery system: enhanced cellular uptake in vitro and improved pharmacokinetics in rats

BACKGROUND: Integrins α(v)β(3) and α(v)β(5), both of which specifically recognize the Arg-Gly-Asp (RGD) motif, are overexpressed on many solid tumors and in tumor neovasculature. Thus, coupling the RGD motif to the liposomal surface for achieving active targeting can be a promising strategy for the...

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Detalles Bibliográficos
Autores principales: Chen, Zhongya, Deng, Jiaxin, Zhao, Yan, Tao, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414220/
https://www.ncbi.nlm.nih.gov/pubmed/22888235
http://dx.doi.org/10.2147/IJN.S33541

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414220/
https://www.ncbi.nlm.nih.gov/pubmed/22888235
http://dx.doi.org/10.2147/IJN.S33541

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